Straight answers on medical weight loss.
GLP-1 medications changed weight loss. Buying them online got confusing fast. We compare the programs, explain what's FDA-approved and what isn't, and show you what it costs before you sign up.
Branded vs compounded
Wegovy and Zepbound are FDA-approved. Compounded versions are not. Here's what that difference means for you.
What it costs
Insurance, self-pay, program fees and the costs nobody puts in the ad.
How online programs work
The visit, the labs, the prescription and what happens if you're not a candidate.
Peptides in 2026
What changed this fall, what a legitimate prescription looks like, and the sellers to avoid.
What these medications do
Semaglutide (Wegovy) and tirzepatide (Zepbound) are FDA-approved for chronic weight management in adults who meet weight criteria, alongside diet and exercise. In the main clinical trials, adults on semaglutide 2.4 mg lost an average of about 15% of body weight over 68 weeks, compared with about 2% on placebo. Adults on the highest dose of tirzepatide lost an average of about 21% over 72 weeks, compared with about 3% on placebo. Individual results vary, and some people lose much less.
Sources: Wilding et al., N Engl J Med 2021 (STEP 1); Jastreboff et al., N Engl J Med 2022 (SURMOUNT-1).
How we're different
- We say plainly which products are FDA-approved and which are compounded.
- We don't run ad trackers on this site. See our privacy policy.
- We list our affiliate relationships and never rank a program higher because it pays more.